A Facile Diversity‐Oriented Multicomponent One‐Pot Synthesis of 3‐Amino‐6,7‐dihydrobenzo[c]thiophen‐4(5H)‐one Derivatives from α‐Oxo‐N,S‐ketene Acetal |
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| Authors: | Swapnil G Yerande Sunil D More Mayur Bhandari Kiran M Newase Kareem Khoury Kan Wang Alexander Dömling |
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| Institution: | 1. Acoris Research Ltd, Pune;2. Department of Pharmaceutical Chemistry, P.E Society's, Modern College of Pharmacy, Pune, India;3. Banasthali Vidyapith, Rajasthan;4. Department of Pharmaceutical Sciences, University of Pittsburgh, Biomedical Science Tower 3, Pittsburgh, Pennsylvania, USA;5. Chair of Drug Design, Department of Pharmaceutical Chemistry (PG), Groningen, The Netherlands |
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| Abstract: | A convenient one‐pot multicomponent method for the preparation of 3‐amino‐6,7‐dihydrobenzoc]thiophen‐4(5H)‐one derivative has been developed. Reaction of 1,3‐cyclohexanedione and phenyl isothiocynate gave α‐oxo‐N,S‐ketene acetal that were reacted in situ with 2‐chloromethylquniazoline‐4‐one derivatives, in the presence of sodium hydride to afford the target compound in reasonable overall yields. |
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