Synthesis of Novel Modified Guanidines: Reaction of Dicyandiamide with Amino Acids,Amides, and Amines in Aqueous Medium |
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| Authors: | Ahmed M Soliman Shaaban K Mohamed Mahmoud Abd El Aleem Ali Ali El‐Remaily H Abdel‐Ghany |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Sohag University, Egypt;2. School of Chemistry and Environmental Science, Manchester Metropolitan University, Manchester, UK |
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| Abstract: | Reaction of dicyandiamide with series of amino acids afforded guanidinyl pyrazolones 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , respectively. Although reaction of dicyandiamide with urea, acetamide, bezamide, allantion, p‐aminobenzoic acid, sulphanilic acid, and adenine gave biguanides 20 , 21 , 22 , 23 , 24 , 25 , 26 , respectively. All compounds have been characterized on the basis of IR and 1H‐NMR. |
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