A Green Synthesis of Pyrrolo[1,2‐a]quinazolin‐5(1H)‐one Derivatives in Ionic Liquids Catalyzed by Iodine |
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| Authors: | Jie‐Xing Zhou Lian Lu Tuan‐Jie Li Chang‐Sheng Yao Xiang‐Shan Wang |
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| Affiliation: | 1. Department of Chemical Engineering, Huaihai Institute of Technology, Lianyungang, People's Republic China;2. School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, People's Republic China |
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| Abstract: | A series of 2,3,3a,4‐tetrahydro‐3a‐methylpyrrolo[1,2‐a]quinazolin‐5(1H)‐one derivatives were synthesized by a reaction of 2‐aminobenzamide and 5‐chloropentan‐2‐one at 80 °C catalyzed by iodine in ionic liquid of [BMIm]Br. Compared with the other methods, this novel method has the advantages of milder reaction conditions, high yields, environmental benignity, and metal‐free catalyst. |
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