Synthesis of Some New Pyrazole,Pyrimidine, Pyridazine,and Their Fused Derivatives from 3‐Oxo‐3,N‐diphenylpropionamide |
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| Authors: | Fathy M Abdelrazek Yehia M Elkholy Ali M Salah Nagwa M Abdelazeem Peter Metz |
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| Institution: | 1. Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt;2. Chemistry Department, Faculty of Science, Helwan University, Helwan, Egypt;3. Institute of Organic Chemistry, TU Dresden, Dresden, Germany |
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| Abstract: | The title compounds were obtained from the reactions of 3‐oxo‐3,N‐diphenylpropionamide 3 with dimethylformamide dimethylacetal followed by hydrazine to afford the pyrazole 7 , condensation with benzaldehyde followed by cyclocondensation with guanidine to afford the pyrimidine derivative 13 , condensation with active methylenes followed by azo coupling of the products followed by cyclization to afford the pyridazines 17a , 17b . The pyridazinone 17b was explored for the synthesis of some novel pyridazine‐fused heterocyclic compounds 19 , 21 , 24a , 24b , 24c , and 26 . All structures were proved via their elemental analyses and spectral data. |
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