Design,Synthesis, and Biological Activities of Novel 2‐Alkylpyrrole Derivatives |
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Authors: | Yongqiang Li Ziwen Wang Pengxiang Zhang Yuxiu Liu Lixia Xiong Qingmin Wang |
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Affiliation: | State Key Laboratory of Elemento‐Organic Chemistry, Institute of Elemento‐Organic Chemistry, Nankai University, Tianjin, People's Republic of China |
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Abstract: | To investigate the alkyl analog of insecticide chlorfenapyr, two series of 2‐alkyl‐4‐bromo‐5‐(trifluoromethyl)pyrrole‐3‐carbonitriles were synthesized with a cycloaddition as the key step. The target products were characterized by 1H‐NMR spectroscopy, elemental analysis, or HRMS. The insecticidal, herbicidal, and antifungal activities of the target compounds were evaluated and found that these compounds did not show much insecticidal activity, but compounds 4 , 10 , and 11 had very good fungicidal activities against Alternaria solani and Fusarium oxysporum. Moreover, compound 4 had an outstanding inhibition effect against pigweed. |
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