Mercury(II) Chloride‐Mediated Desulphurization of Amidinothioureas: Synthesis and Antimicrobial Activity of 3‐Amino‐1,2,4‐triazole Derivatives |
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| Authors: | Swapnil G. Yerande Chetna D. Baviskar Kiran M. Newase Wei Wang Kan Wang Alexander Dömling |
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| Affiliation: | 1. Acoris Research Ltd, Hinjewadi, Pune;2. Department of Pharmaceutical Chemistry, Progressive Education Society's, Modern College of Pharmacy, Nigdi, Pune, India;3. Banasthali Vidyapith, Rajasthan;4. Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA;5. Dept. of Pharm. Chemistry (PG), Chair of Drug Design, AV, Groningen, The Netherlands |
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| Abstract: | The synthesis of 3‐amino‐1,2,4‐triazole via mercury(II) chloride‐mediated cyclization of amidinothiourea is described. This procedure offers a general and efficient route to synthesize the title compound by 3 + 2 annulation reaction. On the basis of the literature precedence, the mechanism for the formation of 3‐amino‐1,2,4‐triazole is proposed. When the synthesized compounds were tested for their antimicrobial activity showed promising inhibition against tested microbes. |
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