Efficient Synthesis and Antibacterial Activities of Some Novel 1,2,3‐Triazoles Prepared from Propargylic Alcohols and Benzyl Azides |
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| Authors: | Rahman Hosseinzadeh Mohammadreza Khadem Abolfazli Mojtaba Mohseni Maryam Mohadjerani Zahra Lasemi |
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| Affiliation: | 1. Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran;2. Department of Biology, Faculty of Science, University of Mazandaran, Babolsar, Iran;3. Islamic Azad University, Iran |
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| Abstract: | A simple and effective procedure for regioselective preparation of 1,2,3‐triazoles from benzyl azides and propargylic alcohols is described using CuSO4.5H2O and sodium ascorbate. To screen the antibacterial activity of some newly synthesized triazole derivatives, minimum inhibitory concentration of 3d and 3k was evaluated against gram positive Staphylococcus aureus and Bacillus subtilis and gram negative Escherichia coli and Pseudomonas aeruginosa. |
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