The Behavior of 2‐Substituted‐3‐hydroxyisoindolinones in the Reaction with sec‐Butyllithium |
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| Authors: | A Jó?wiak M Ciechańska |
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| Institution: | Department of Organic Chemistry, Faculty of Chemistry, University of ?ód?, ?ód?, Poland |
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| Abstract: | This paper presents a dualistic behavior of 2‐substituted‐3‐hydroxyisoindolones in reactions with sec‐butyllithium (sec‐BuLi). 2‐tert‐Butyl‐3‐hydroxy‐2,3‐dihydro‐1H‐isoindol‐1‐one ( 1a ) treated with sec‐BuLi undergoes metalation at position 7. On the other hand, the reaction between 3‐hydroxy‐2‐phenyl‐2,3‐dihydroxyisoindol‐1‐one ( 1j ) and sec‐BuLi results in 3‐sec‐butyl‐2‐phenyl‐2,3‐dihydroisiondol‐1‐one ( 3j ). |
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