Synthesis of Amide and Ester Derivatives of Naphthopyrone Carboxylic Acid |
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Authors: | J N Soni S S Soman |
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Institution: | Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India |
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Abstract: | The synthesis of various amide and ester derivatives of naphthopyrone‐2‐carboxylic acid has been carried out by reaction of 1‐naphthol with dimethyl acetylenedicarboxylate, which gave a mixture of E and Z isomers of naphthoxy diester. The diester on hydrolysis with KOH gave corresponding diacid, which was a mixture of E and Z isomers. The E and Z isomers were difficult to separate, which were subjected to cyclization in sulfuric acid to get cyclized naphthopyrone carboxylic acid. This acid is converted into titled compounds. |
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