Microwave‐Assisted One‐Pot Synthesis of Substituted 3‐Bromoimidazo[1,2‐a]pyridines and Imidazoheterocycles |
| |
| Authors: | Shashikant M Patil Malcolm Mascarenhas Rajiv Sharma S Mohana Roopan Abhijit Roychowdhury |
| |
| Institution: | 1. Department of Medicinal Chemistry, Piramal Healthcare Ltd., Mumbai, India;2. Organic Chemistry Division, School of Advanced Sciences, VIT University, Tamil Nadu, India |
| |
| Abstract: | Herein, an efficient, one‐pot microwave‐assisted synthesis of a diverse set of 3‐bromoimidazo1,2‐a]pyridines is being reported with good yields (40–85%). The method involves electrophilic aromatic bromination using bromodimethylsulfonium ion generated in situ via oxidation of HBr salt by DMSO. This methodology was also applied to the synthesis of related imidazoheterocycles. Copyright © 2014 HeteroCorporation |
| |
| Keywords: | |
|
|
