Synthesis of New Hybrid Heterocyclic Compounds Having 1,2,3‐Triazole and Isoxazole via Click Chemistry |
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| Authors: | Y. Jayaprakash Rao A. Srinivas |
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| Affiliation: | Post Graduate College of Science, Saifabad, Osmania University, Hyderabad, India |
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| Abstract: | A simple and highly efficient method for the regioselective synthesis of isoxazolyl‐1,4‐disubstituted‐1,2,3‐triazoles 6a , 6b , 6c , 6d , 6e , 6f , 6g , 6h , 6i , 6j , 6k , 6l in good to excellent yields from terminal alkynes having isoxazole scaffold 4a , 4b , 4c and various azides through Cu(I)‐catalyzed 1,3‐dipolar cycloaddition is described. The reaction proceeds smoothly in 1:1 mixture of t‐BuOH and water at RT. The structures of all newly synthesized hybrid heterocycles are established on the basis of spectral data ir, 1H nmr, mass, and elemental analysis. |
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