Studies on Synthesis of Novel Triazole Tagged Pyrazole Fused Naphthalene 5‐Thiazine‐5,5‐dioxide Derivatives,Their Antimicrobial,and Antioxidant Activity |
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| Authors: | G Malla Reddy P Nagender R Naresh Kumar J H Ahn K Pranay Kumar A K R Kanugula K V S Rama Krishna S Kotamraju B Narsaiah |
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| Institution: | 1. Fluoroorganic Division, Indian Institute of Chemical Technology, Hyderabad, India;2. Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, South Korea;3. Biology Division, Indian Institute of Chemical Technology, Hyderabad, India;4. Department of Chemical Biology, Indian Institute of Chemical Technology, Hyderabad, India;5. NMR Division, Indian Institute of Chemical Technology, Hyderabad, India |
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| Abstract: | A series of novel triazole tagged pyrazole fused naphthalene‐5‐thiazine‐5,5‐dioxide derivatives 8 and 9 were synthesized starting from sodium salt of saccharin 1 . The structure of each intermediate and products was established on the basis of spectroscopy data. All the synthesized compounds 8 and 9 were screened against various bacterial and fungal strains but found to show no activity up to 150‐µg/mL concentration. Further screening for antioxidant property resulted promising compounds. |
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