An Efficient Synthesis of 3H‐Pyrrolo[3,2‐d]pyrimidin‐4(5H)‐one Derivatives via an Iminophosphorane |
| |
| Authors: | Ping He Yan‐Mei Yan Ming‐Wu Ding |
| |
| Institution: | 1. Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan, People's Republic of China;2. College of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang, People's Republic of China |
| |
| Abstract: | The iminophosphorane ( 3 ), obtained from reaction of ethyl 3‐amino‐4‐cyano‐1‐phenyl‐1H‐pyrrole‐2‐carboxylate ( 2 ) with triphenylphosphine, hexachloroethane, and triethylamine, reacted with aromatic isocyanates to give carbodiimides ( 4 ). Further reaction of 4 with various amines, phenols, or ROH to give 2,3,5,7‐tetrasubstituted 3H‐pyrrolo3,2‐d]pyrimidine‐4(5H)‐ones ( 6 ) in satisfactory yields in the presence of catalytic amount of sodium alkoxide or solid potassium carbonate. |
| |
| Keywords: | |
|
|
