Use of the silylation reaction in synthesis of fragment 1–4 of the ACTH sequence

A new effective method of synthesizing fragment 1–4 of the ACTH sequence ensuring a high overall yield of the desired product is proposed. This result is achieved thanks to the wide use of the silylation reaction in the synthesis, which has permitted a considerable simplification of the process and the avoidance of the formation of by-products. The peptides synthesized have been characterized by their angles of optical rotation, chromatographic mobilities, and melting points. A table of chemical shifts in the¹³C NMR spectra of the final and intermediate compounds is given.All-Union Research Institute of Technology of Blood Substitutes and Hormone Preparations, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 248–253, March–April, 1988.