A novel one-pot method for the preparation of pyrazoles by 1,3-dipolar cycloadditions of diazo compounds generated in situ |
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| Authors: | Aggarwal Varinder K de Vicente Javier Bonnert Roger V |
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| Institution: | School of Chemistry, Bristol University, Cantock's Close, Bristol BS8 1TS, UK. v.aggarwal@bristol.ac.uk |
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| Abstract: | A convenient one-pot procedure for the preparation of pyrazoles by 1,3-dipolar cycloaddition of diazo compounds generated in situ has been developed. Diazo compounds derived from aldehydes were reacted with terminal alkynes to furnish regioselectively 3,5-disubstituted pyrazoles. Furthermore, the reaction of N-vinylimidazole and diazo compounds derived from aldehydes gave exclusively 3-substituted pyrazoles in a one-pot process. |
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