Synthesis of asymmetrical tridendate Schiff bases and metal complexes and investigation of anticarcinogen effects on human colon and cervical cancers |
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| Authors: | Mustafa Sahin Hatice Korkmaz Nuriye Kocak Ozlem Sahin Serdar Karakurt |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Selcuk University, Konya, Turkey;2. Department of Science Education, Faculty of Education, Necmettin Erbakan University, Konya, Turkey;3. Department of Biochemistry, Faculty of Science, Selcuk University, Konya, Turkey |
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| Abstract: | The metal complexes of Zn(II), Ni(II), Cu(II) and Pb(II) with asymmetrical Schiff bases were synthesized. The asymmetrical Schiff base was obtained through the condensation of 1,2-phenylenediamine, 4-methyl-1,2-phenylenediamine, 2-hydroxy-1-napthaldehyde and biphenyl-4-carbaldehyde. The new Schiff base ligands (L1' and L2') and their metal complexes were characterized by TG/DTG, FT-IR, 1H-NMR, UV–Vis, ESR, powder XRD, elemental analysis, magnetic moment and fluorescence studies. The powder XRD studies indicate that Co(II) and Cu(II) complexes are amorphous, while Ni(II) and Zn(II) complexes are crystalline. The anticarcinogenic effects of L1' and L2' were also investigated against colon (SW-620) and cervical cancer (HeLa) cell lines and compound L2' was found to possess the highest anticarcinogenic potential, with 16.7 µM and 27.5 µM of IC50 values for HeLa and SW620 cells, respectively. |
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| Keywords: | Anticancer activity ESR metal complexes Schiff base XRD |
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