One-pot synthesis of PDMAEMA nanocapsules for controlled release of hydrophobic cargo |
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| Authors: | Lin Wu Yiguo Li Tao Pang Ye-bin Guan |
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| Institution: | 1. Anhui Key Laboratory of Functional Coordination Compounds, School of Chemistry and Chemical Engineering, Anqing Normal University, Anqing, China;2. Department of Colour Science, School of Chemistry, University of Leeds, Leeds, LS2 9JT, UKwulinaqsfxy@163.com;4. Collaborative innovation Center for Petrochemical New Materials, Anqing, China |
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| Abstract: | In this work, poly((N,N-dimethyl amino)ethyl methacrylate) (PDMAEMA) homopolymers are synthesized using RAFT technique, which is then used as stabilizers to prepare miniemulsion droplets in a toluene/hexadecane(HD)/1,2-Bis-(2-iodoethyl)ethane(BIEE)/hydrophobic molecule/water mixture. Upon the reaction between BIEE and the stabilizers of miniemulsion droplets, the polymeric nanocapsules are formed and capable of encapsulating hydrophobic molecule in their oil core in one-step reaction. The release of hydrophobic cargo from the nanocapsules can be controlled by the variation of amount of surfactant (Tween®20) in the release medium and a long duration sustained release was achieved. |
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| Keywords: | Polymeric nanocapsules miniemulsion crosslinking PDMAEMA homopolymer hydrophobic cargo controlled release |
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