Practical preparation of mono- and di-O-isopropylidene derivatives of monosaccharides and methyl 4,6-O-benzylidene glycosides from free sugars in a deep eutectic solvent |
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| Authors: | Sunil M Rokade |
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| Institution: | Department of Dyestuff Technology, Institute of Chemical Technology, Mumbai, Maharashtra, India |
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| Abstract: | Free sugars were rapidly converted into the corresponding di-O-isopropylidene derivatives and methyl O-benzylidene glycosides in excellent yields and purity in a deep eutectic solvent made from choline chloride and malonic acid (ChCl:MA). Reaction conditions were mild; work-up was easy, and further purification was not necessary. Given the inexpensive, nontoxic, and recyclable nature of ChCl:MA, this protocol is environmental friendly. |
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| Keywords: | Deep eutectic solvents methyl O-benzylidene glycosides O-Isopropylidene sugar derivatives |
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