Efficient conversion of tomatidine into neuritogenic pregnane derivative |
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| Authors: | Matsushita Sayaka Yanai Yoshihiro Fusyuku Asami Fujiwara Yukio Ikeda Tsuyoshi Ono Masateru Han Chunguang Ojika Makoto Nohara Toshihiro |
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| Affiliation: | Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan. |
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| Abstract: | Moderate acetylation of tomatidine with anhydrous acetic acid and pyridine for 20 h at r.t., followed by pseudomerization in ice-water, gave a delta(20(22))-pseudo compound, which was then subjected to ozonolysis to provide a pregnane derivative in a total 54% yield showing neuritogenic and NGF-enhancing activities. |
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