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In vivo sodium-23 magnetic resonance surface coil imaging: Observing experimental cerebral ischemia in the rat |
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| Authors: | Michael E. Moseley Ph.D. Wil M. Chew B.S. Merry C. Nishimura B.S. Todd L. Richards Ph.D. Joseph Murphy-Boesch Ph.D. Gregory B. Young Ph.D. Thomas M. Marschner Ph.D. Lawrence H. Pitts M.D. Thomas L. James Ph.D. |
| Affiliation: | a Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, USA * Department of Neurosurgery, University of California, San Francisco, San Francisco, California 94143, USA |
| Abstract: | Sodium-23 magnetic resonance imaging can be used to detect and assess experimental cerebral ischemia in the rat. An imaging technique utilizing a surface coil is described to produce sodium magnetic resonance images of good quality and resolution within 10 min. A novel method of hemispheric occlusion showed edema in the right brain of the rat head within 3 hr after injury. The edema was especially pronounced by 12 hr with effects in the right brain, eye and surrounding muscle evident. |
| Keywords: | Author Keywords: Magnetic resonance imaging Sodium magnetic resonance Brain edema Injury time course |
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