Catalytic enantioselective approach to the stereodivergent synthesis of (+)-lasubines I and II |
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| Authors: | Mancheño Olga García Arrayas Ramón Gómez Adrio Javier Carretero Juan C |
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| Institution: | Departamento de Química OrgAnica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. |
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| Abstract: | A concise and efficient approach to the stereodivergent synthesis of (+)-lasubines I and II is described. The key common intermediate is a chiral N-sulfonyl 2,3-dihydropyridone obtained by a novel Cu-catalyzed asymmetric formal aza-Diels-Alder reaction between N-tosyl aldimines and Danishefsky's diene. |
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