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Efficient microwave combinatorial parallel and nonparallel synthesis of N-alkylated glycine methyl esters as peptide building blocks |
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| Authors: | Santagada Vincenzo Frecentese Francesco Perissutti Elisa Fiorino Ferdinando Severino Beatrice Cirillo Donatella Terracciano Sara Caliendo Giuseppe |
| Institution: | Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli Federico II, Via D. Montesano, 49, 80131 Naples, Italy. santagad@unina.it |
| Abstract: | An easy and convenient microwave-assisted synthesis of N-alkylated glycine methyl esters is described. Parallel and nonparallel combinatorial methods are described and compared. The described reactions are reductive alkylations of several aldehydes and glycine methyl ester in the presence of NaBH3CN. Good yields and short reaction times are the main aspects of these procedures. |
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