One-pot borylation/amination reactions: syntheses of arylamine boronate esters from halogenated arenes |
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| Authors: | Holmes Daniel Chotana Ghayoor A Maleczka Robert E Smith Milton R |
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| Affiliation: | Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA. |
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| Abstract: | [reaction: see text] A one-pot protocol for converting 1,3- and 1,4-substituted aryl halides to arylamine boronate esters is described. This is achieved by sequential Ir-catalyzed aromatic borylation at the least hindered C-H bond of the aryl halide and subsequent Pd-catalyzed C-N coupling at the halide position of the crude arylboronic ester. |
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