Institution: | a Department of Chemistry, Pohang University of Science & Technology, Pohang 790-784, Korea b Yuhan Research Center, Gunpo, Kyunggi-do 435-030, Korea |
Abstract: | A series of lanosterol and cholesterol derivatives with modified side chain structures, which might interfere with sterol C24-methyltransferase in the ergosterol biosynthesis as substrate analogs, have been synthesized. The in vitro bioassay studies have shown that some of these compounds, in particular with C24-amino- and thio-functionalities, possess potent antifungal activities, in vivo. Bioassays have also been carried out for the leading compounds. |