New Synthesis of 2-Deoxy-2-fluoro-D-hexoses by Fluorination in Water |
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| Authors: | Mirko Diksic Dean Jolly |
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| Institution: | Neuro Imaging Research, Montreal Neurological Institute and Hospital, McGill University , 3801 University St., Montreal, Que., H3A 2B4, CANADA |
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| Abstract: | Interest in fluorinated sugars labelled with {18F} positron-emitting radionuclides as tracers for the measurement of glucose utilization in man by positron emission tomography1 (PET) and in animals by autoradiography2 has resulted in the development of numerous syntheses3-11 of 2-deoxy-2-fluoro-D-glucose (3a). Some of these syntheses are not practical because the carbohydrate substrates for the fluorination reactions are not readily available. |
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