Some Physico-Chemical and Biological Properties of Triazeno Sugars |
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| Authors: | Jean M. J. Tronchet Françoise Barbalat-Rey Jeannine F. Tronchet Faranak Raehidzadeh |
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| Affiliation: | Institut de Chiraie Pharmaceutique de l'Université 30 , Quai Ernest-Ansermet, 1211, Geneve 4, Switzerland |
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| Abstract: | Replacement of the alkyl group of l-aryl-3-alkyltriazenes with a sugar moiety did not significantly modify their tautomeric behaviour. The same replacement done on 1-aryl-3-alkyl-3-methyl-triazenes did not affect to any large extent their rotameric properties. In contrast, the most prominent biological properties, anticancer activity and toxicity, of 1-aryl-3-methyltria-zenes disappeared on replacement of the methyl group with a sugar moiety. Unexpectedly, the N-acetyltriazene 15 was highly cyto-toxic. |
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