Synthesis of Sugars From D-Ribonolactone. II. An Alternative Synthesis of D-Erythrose |
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| Authors: | Ramesh H Shah |
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| Institution: | Department of Pharmaceutical Sciences , College of Pharmacy and Allied Health Professions St. John's University Jamaica , New York , 11439 , U.S.A. |
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| Abstract: | D-Erythrose was synthesized in four steps from D-ribono-1,4-lactone via the 3,5-O-benzylidene derivative of the latter compound. Reduction of the benzylidene D-ribonolactone, and periodate cleavage of the resulting 3,5-O-benzylidene-D- ribitol were performed in a one-flask reaction. The ensuing 2,4-O-benzylidene-D-erythrose was hydrolyzed with 10% acetic acid to obtain syrupy D-erythrose. |
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