Synthetic Approach Toward Antibiotic Tunicamycins - VII Synthesis of Tunicamine and Tunicaminyl Uracil Derivative |
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| Authors: | Hiroaki Sasai Kazuhiro Matsuno Tetsuo Suami |
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| Institution: | Department of Applied Chemistry Faculty of Science and Technology , Keio University , Hiyoshi, Yokohama, 223, Japan |
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| Abstract: | A higher carbon carbohydrate moiety of antibiotic tunica-mycins named tunicamine has been synthesized in a protected form. The key reaction step of the synthesis is a potassium fluoride catalyzed Henry reaction of a 5-nitroribose derivative and a dial do-galactosamine derivative. The tunicamine derivative has been converted to a tunicaminyl uracil derivative by condenation with bis(trimethylsilyl) uracil. |
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