Pyrrolidinyl peptide nucleic acid homologues: effect of ring size on hybridization properties |
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| Authors: | Mansawat Woraluk Vilaivan Chotima Balázs Árpád Aitken David J Vilaivan Tirayut |
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| Affiliation: | Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand. |
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| Abstract: | The effect of ring size of four- to six-membered cyclic β-amino acid on the hybridization properties of pyrrolidinyl peptide nucleic acid with an alternating α/β peptide backbone is reported. The cyclobutane derivatives (acbcPNA) show the highest T(m) and excellent specificity with cDNA and RNA. |
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