Genes within the serotonergic system are differentially expressed in human brain |
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| Authors: | Karen Sugden Ales Tichopad Nadeem Khan Ian W Craig Ursula M D'Souza |
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| Institution: | (1) MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, King's College, London, UK;(2) Physiology Weihenstephan, Center of Life and Food Sciences (ZIEL), Technical University of Munich, 85350 Freising, Germany;(3) Department of Neuropathology, Brain Bank, Institute of Psychiatry, King's College, London, UK |
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| Abstract: | Background Serotonin is an important neurotransmitter with wide-ranging functions throughout the central nervous system. There is strong
evidence to suggest that regulation of serotonergic gene expression might be related to genetic variability, and several studies
have focused on understanding the functional effects of specific polymorphisms within these genes on expression levels. However,
the combination of genotype together with gender and brain region could have an overall effect on gene expression. In this
study, we report expression patterns of five serotonergic genes (TPH1, TPH2, 5-HT2A, 5-HT2C, 5-HTT) in seven different human post-mortem brain regions (superior frontal gyrus, superior temporal gyrus, striatum, cerebellum,
hippocampus, midbrain and thalamus) using TaqMan™ real-time quantitative PCR. In addition, the effect of genotype and gender
on their expression levels was determined. |
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