Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides |
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Authors: | Wu Zhimeng Guo Xueqing Guo Zhongwu |
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Institution: | Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA. |
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Abstract: | A chemoenzymatic method was developed for the synthesis of macrocyclic peptides and glycopeptides. Sortase A was found to mediate either head to tail cyclization or oligomerization and then head to tail cyclization of peptides and glycopeptides, depending on the peptide length, to produce 15-mer or higher cyclic peptides and glycopeptides. |
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