Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins |
| |
| Authors: | Qian Jiang Klomsiri Chananat Wright Marcus W King S Bruce Tsang Allen W Poole Leslie B Furdui Cristina M |
| |
| Institution: | Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA. |
| |
| Abstract: | Facile, two-step synthesis and kinetic characterization of new chemical probes for selective labeling of sulfenic acid (-SOH) in proteins are presented. The synthesis route relies on the simple and highly efficient Michael addition of thiol containing tags or linkers to 4-cyclopentene-1,3-dione, the unsaturated derivative of 1,3-cyclopentanedione. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
