磷酸钙骨水泥/聚肽共聚物生物复合材料力学性能及微观结构

磷酸钙骨水(Calcium Phosphate Cement，CPC)是一种新型的人工骨材料，可用于人体骨缺损的修复，具有良好的生物相容性、骨传导性和骨替代性．然而，磷酸钙骨水泥的抗压强度较低，脆性较大，限制了其应用，因而提高抗压强度和减小其脆性成为CPC研究领域的一个重要课题．目前，普遍采用添加纤维的方法来提高CPC材料的抗压强度和韧性．然而大多数的纤维是非降解性的．

Mechanical Property and Microstructure of Biological Material of Calcium Phosphate Cement/Polypeptide Copolymer

Polypeptide graft copolymers such as poly(γ-benzyl-L-glutamate)(PBLG)-poly(ethylene glycol)(PEG) and poly(γ-ethyl-L-glutamate)(PELG)-poly(ethylene glycol)(PEG) were introduced into self-setting calcium phosphate cement(CPC) system to improve its mechanical properties. The compression strength was improved considerably by the induction of polypeptide copolymers. It is about 22.3 higher for PBLG-g-PEG and 65.0 higher for PELG-g-PEG, respectively. The results also show that for the same polypeptide copolymer, higher compression strength of composites can be obtained by introducing copolymer micelles into the CPC. According to the results of scanning electron microscope(SEM), the crystallite shapes of CPC depend on the weight fraction of polypeptide copolymer in the composites.