Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue |
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| Authors: | Tomlinson John T Park Gyungse Misenheimer Jacob A Kucera Gregory L Hesp Kevin Manderville Richard A |
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| Affiliation: | Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, USA. |
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| Abstract: | [reaction: see text] The prodigiosin alkaloid 1 and the synthetic analogue 2 show photoinduced cytotoxicity against HL-60 cancer cells. Photoirradiation of 1 and 2 causes photofading, photooxidation, and thioadduct formation. These results provide a model for the redox properties of prodigiosins that play a role in their biological activity and provide a new way to functionalize their pyrromethene entity with water-soluble thiol groups. |
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