Complete assignments of 1H and 13C NMR data for trypanocidal eremantholide C oxide derivatives |
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Authors: | Saúde-Guimarães Dênia A Perry Katia S P Raslan Délio S Chiari Egler Barrero Alejandro F Oltra Juan E |
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Institution: | LAPLAMED, DEFAR, Escola de Farmácia, Universidade Federal de Ouro Preto, Rua Costa Sena, 171, CEP 35400-000, Ouro Preto, Minas Gerais, Brazil. saude@ef.ufop.br |
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Abstract: | The chemical transformations of eremantholide C (1), a trypanocidal sesquiterpene lactone isolated from Lychnophora trichocarpha Spreng., gave five new oxide derivatives: 3'-hydroxyeremantholide C (2), 1'-formyleremantholide C (3), 1'-carboxyeremantholide C (4), 1'-carbomethoxyeremantholide C (5) and sodium 1'-carboxylate of eremantholide C (6). The (1)H and (13)C NMR data of all these derivatives were assigned based on 1D and 2D techniques. The derivatives were evaluated against Y and CL strains of Trypanosoma cruzi. All of them were inactive against the Y strain. Compounds 2 and 5 displayed 100% activity on the CL strain while compounds 4 and 6 were partially active on the CL strain. |
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Keywords: | NMR 1H NMR 13C NMR 2D NMR eremantholide C Lychnophora trichocarpha sesquiterpene lactone eremantholide C derivatives trypanocidal activity |
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