Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications |
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| Authors: | Yanbao Gong Mingxia Fan Feng Gao Jun Hong Shunying Liu Shufang Luo Jiahui Yu Jin Huang |
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| Institution: | aCollege of New Drug Innovation Research & Development, East China Normal University, Shanghai 200062, PR China;bShanghai Key Laboratory of FMRI, East China Normal University, Shanghai 200062, PR China;cCollege of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, PR China |
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| Abstract: | To design peptide-targeted iron oxide as magnetic resonance imaging (MRI) contrast agents, amino-functionalized magnetic nanogels were prepared by using N-(2-aminoethyl) methacrylamide hydrochloride (AEM·HCl) as monomer via new photochemical approach. Their chemical structure and composition were characterized by Fourier transform infrared spectra (FTIR) and thermogravimetric analyses (TGA). The core–shell structure of magnetic nanogels was confirmed by high-resolution transmission electron microscopy (HRTEM). The good storage stability, high magnetic content (88.7%), high saturation magnetizations and superparamagnetic behavior suggested their great potentials as MRI contrast agents, which were confirmed by their measurements of r2 and coronal image of the crossing of mouse kidney. |
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| Keywords: | Photopolymerization Core– shell magnetic nanogels Amino-functionalized Superparamagnetism Magnetic resonance imaging (MRI) |
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