Sulfanylamide-containing coordination compounds of 3d-elements with 2,4-pentanedione bis-thiosemicarbazone and bis-4-phenylthiosemicarbazone

Thiosemicarbazide and 4-phenylthiosemicarbazide react in ethanol with 2,4-pentanedione in the presence of manganese, cobalt, nickel, copper, and zinc acetates hydrates and streptamin (Sf¹), sulfaethidole (Sf²), and sulfadimidine (Sf³) to form coordination compounds of the composition M(Sf^1–3)(L^1–2) · nH₂O (M = Mn, Co, Ni, Cu, Zn; H₂L¹ is 2,4-pentanedione bis-thiosemicarbazone, H₂L² is 2,4-pentanedione bis-4-phenylthiosemicarbazone; n = 0–6). All the complexes synthesized are monomeric. Thiosemicarbazones (H₂L¹ and H₂L²) behave as twice deprotonated S,N,N,S-tetradentate ligands, while sulfanylamides (Sf^1–3) act as monodentate ones. Thermolysis of these substances proceeds through the stages of dehydration (65–95°C) and complete thermal decomposition (430–560°C). It is found that the complex Cu(Sf²)(L¹)] · 4H₂O in the concentration 10^?5 M inhibits the growth and fission of 100% cancer cells of the human myeloid leukemia (HL-60).