一种全合成型人工红血球的研究进展

一种全合成型人工红血球的研究进展;人工红血球;全合成型白蛋白－血红素载体;氧气输送;安全性;综述

Progress on the Totally Synthesized Artificial Red Blood Cell

rHSA heme is the first obtained totally synthesized artificial blood cell substitute. Recombinant albumin associated with synthetic heme has the sufficient capacity to bind and release oxygen molecules under physiological conditions and is practically used in clinical trial with satisfaction. By mixing rHSA heme with blood in vitro , the concentration of the heme could maintain stable without heme transference. No effect was confirmed on the number of the blood cells, the morphology of the red blood cells and the blood coagulation system. All the rats were survived by injection of rHSA heme solutions after the hemodilution and hemorrhage, and nearly all the physiological response parameters could be recovered. The safety experiments have also proved that the rHSA heme solution has no poisonous effect on the function of the rats. rHSA heme is hope fully to be a new generation of the artificial red blood cell substitute.