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Studies of bimetallic carboxylates: their synthesis, characterization, biological activity and X-ray structure |
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| Authors: | Imtiaz-ud-Din Khalid M. Khan K.C. Molloy |
| Affiliation: | a Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan b HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan c Department of Chemistry, University of Bath, Bath BA2 7AY, UK |
| Abstract: | Ten novel diorganotin dicarboxylates containing germanium in the carboxylate ligand have been synthesized and their structures have been characterized by IR, Mössbauer and multinuclear NMR (1H, 13C, 119Sn) spectroscopies and X-ray diffraction. Also, the twodiastereotopic protons of the methylene group which are directly attached to the chiral center in these compounds have been successfully analyzed for the first time. The resulted ABX system gives three coupling constants and three chemical shifts. The single crystal X-ray analysis of precursor (p-CH3C6H4)3GeCH(p-CH3C6H4)CH2COOH revealed the dimeric structure of the molecule through H-bonding between carboxylic acid groups in a conventional manner. The results of their biological activity suggest that the materials have potential to be used as drugs. |
| Keywords: | Synthesis Diorganotindicarboxylates Germanium Spectroscopy Diastereotopy X-ray structure Biological activities |
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