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Potential inhibitors of DNA topoisomerase II: ruthenium(II) poly-pyridyl and pyridyl-azine complexes |
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| Authors: | Manish Chandra D.S. Pandey R.P. Tripathi V.J.M. Reddy Pedro Valerga |
| Affiliation: | a Department of Chemistry, Awadhesh Pratap Singh University, Rewa 486 003 (M.P.), India b Medicinal and Biochemistry Division, Central Drug Research Institute, P.B. No.173, Chattar Manzil, Lucknow (U.P.), India c Departmento de Ciencia de los Materiales e Ingenieria Metallurgica y Quimica Inorganica, Facultad de Ciencia, Universidad de Cadiz, Apartado - 40, Puerto Real 11510, Spain |
| Abstract: | In search of new DNA probes a series of new mono and binuclear cationic complexes [RuH(CO)(PPh3)2(L)]+ and [RuH(CO)(PPh3)2(-μ-L)RuH(CO)(PPh3)2]2+ [L=pyridine-2-carbaldehyde azine (paa), p-phenylene-bis(picoline)aldimine (pbp) and p-biphenylene-bis(picoline)aldimine (bbp)] have been synthesized. The reaction products were characterized by microanalyses, spectral (IR, UV-Vis, NMR and ESMS and FAB-MS) and electrochemical studies. Structure of the representative mononuclear complex [RuH(CO)(PPh3)2(paa)]BF4 was crystallographically determined. The crystal packing in the complex [RuH(CO)(PPh3)2(paa)]BF4 is stabilized by intermolecular π-π stacking resulting into a spiral network. Topoisomerase II inhibitory activity of the complexes and a few other related complexes [RuH(CO)(PPh3)2(L)]+ {L=2,4,6-tris(2-pyridyl)-1,3,5-triazine (tptz) and 2,3-bis(2-pyridyl)-pyrazine (bppz)} have been examined against filarial parasite Setaria cervi. Absorption titration experiments provided good support for DNA interaction and binding constants have also been calculated which were found in the range 1.2 × 103-4.01 × 104 M−1. |
| Keywords: | Ruthenium Poly-pyridyl and pyridyl-azine ligands Hydride DNA Topoisomerase II π-π interaction |
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