Synthesis and reactions of silicon containing cyclic α-amino acid derivatives |
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| Authors: | Sambasivarao Kotha Enugurthi Brahmachary |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology - Bombay, Powai, Mumbai 400 076, India |
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| Abstract: | A simple synthesis of a new amino acid derivative 5,6-bis(trimethylsilyl)indanylglycine via cobalt mediated [2 + 2 + 2] cycloaddition strategy is described. Co-trimerization of diyne building block containing amino acid moiety with bis(trimethylsilyl)acetylene in presence of CpCo(CO)2 catalyst afforded the silylated indane-based α-amino acid (AAA) derivative. Electrophilic aromatic substitution reaction, ipso to the trimethylsilyl group gave highly functionalised indane-based AAA derivatives. |
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| Keywords: | Unusual amino acids [2 + 2 + 2] cycloaddition Silicon amino acids Cyclopentadienyl cobalt dicarbonyl Ipso substitution |
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