General and efficient methodology for the Suzuki-Miyaura reaction in technical grade 2-propanol |
| |
Authors: | Oscar Navarro Roy A Kelly Oliver Briel |
| |
Institution: | a Department of Chemistry, University of New Orleans, New Orleans, LA 70148, USA b Umicore AG&Co KG, P.O. Box 1351, D-63403 Hanau, Germany |
| |
Abstract: | The reaction profile of a series of palladium-based catalysts was examined in the Suzuki-Miyaura reaction using technical grade 2-propanol as solvent and potassium t-butoxide as base. The results generally show high activity. The method allows for the coupling of electron-rich aryl chlorides with sterically hindered aryl boronic acids to produce tri-ortho-substituted biaryls in high yields using very mild conditions and short reaction times. |
| |
Keywords: | Suzuki-Miyaura reaction Palladium Catalysis N-heterocyclic carbene |
本文献已被 ScienceDirect 等数据库收录! |