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Both systemic and local application of Granulocyte-colony stimulating factor (G-CSF) is neuroprotective after retinal ganglion cell axotomy |
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| Authors: | Tobias Frank Johannes CM Schlachetzki Bettina G?ricke Katrin Meuer Gundula Rohde Gunnar PH Dietz Mathias B?hr Armin Schneider Jochen H Weishaupt |
| Affiliation: | 1. Department of Neurology, University Medical Center G?ttingen, Robert-Koch-Strasse 40, 37075, G?ttingen, Germany 2. DFG-Research Center for Molecular Physiology of the Brain (CMPB), Humboldtallee 23, G?ttingen, Germany 3. H Lundbeck A/S, 2500, Valby, Denmark 4. Sygnis Bioscience, Im Neuenheimer Feld 515, 69120, Heidelberg, Germany |
| Abstract: | BackgroundThe hematopoietic Granulocyte-Colony Stimulating Factor (G-CSF) plays a crucial role in controlling the number of neutrophil progenitor cells. Its function is mediated via the G-CSF receptor, which was recently found to be expressed also in the central nervous system. In addition, G-CSF provided neuroprotection in models of neuronal cell death. Here we used the retinal ganglion cell (RGC) axotomy model to compare effects of local and systemic application of neuroprotective molecules. |
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