A mononuclear complex of copper(II) with a calcium channel antagonist nifedipine. Synthesis,properties, crystal structure |
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| Authors: | Bontchev Panayot R. Mehandjiev Dimitar R. Ivanova Bojidarka B. Bontchev Ranko P. |
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| Affiliation: | (1) Bulgarian Academy of Sciences, Institute of General and Inorganic Chemistry, Sofia, 1113, Bulgaria;(2) Faculty of Chemistry, Sofia University, 1.J.Bourchier blvd., Sofia, 1164, Bulgaria;(3) Sandia National Laboratories, P.O. Box 5800, MS 0755, Albuquerque, NM 87185-0755, USA |
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| Abstract: | The complexation processes between the calcium channel antagonist drug nifedipine (Nif) and CuII lead to the formation of a mononuclear violet complex CuNif2Cl2(1). Monocrystals of (1) were isolated and their structure determined by X-ray diffraction. Copper is coordinated through N of the NH group of the ligand. The metal ion is coordinated also with two Cl– anions and the geometry of the CuN2Cl2 core is a near flat square. The magnetic and optical properties of (1) were also studied using electronic and i.r. spectra, e.p.r. and magnetochemical measurements. |
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