Prefolded Synthetic G‐Quartets Display Enhanced Bioinspired Properties |
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| Authors: | Theodore Flack Thibaut Constantin Sylvain Penasse Dr. Jérôme Dejeu Béatrice Gennaro Dr. Muriel Jourdan Aurélien Laguerre Marc Pirrotta Dr. David Monchaud Dr. Nicolas Spinelli Prof. Eric Defrancq |
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| Affiliation: | 1. Université Grenoble Alpes, Département de Chimie Moléculaire, CNRS UMR 5250, Grenoble, France;2. Institut de Chimie Moléculaire, Université de Bourgogne (ICMUB), CNRS UMR 6302, Dijon, France |
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| Abstract: | A water‐soluble template‐assembled synthetic G‐quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase‐type biocatalytic activities and improved quadruplex‐interacting properties. Comparison of its DNAzyme‐boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme‐boosting agent. |
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| Keywords: | cyclodecapeptide DNAzyme G-quadruplexes G-quartets supramolecular chemistry |
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