Generation of Oxazolidine‐2,4‐diones Bearing Sulfur‐Substituted Quaternary Carbon Atoms by Oxothiolation/Cyclization of Ynamides |
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| Authors: | Hai Huang Junzhen Fan Dr. Guangke He Zhimin Yang Xiaodong Jin Qi Liu Prof. Dr. Hongjun Zhu |
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| Affiliation: | Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, P. R. China |
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| Abstract: | A novel method for metal‐free oxothiolation of ynamides to construct oxazolidine‐2,4‐diones bearing sulfur‐substituted quaternary carbon atoms has been developed. It represents a rare C?O bond cleavage of ynamides, as well as a facile and tandem approach for the formation of C?O, C?S, and C?Cl bonds. This redox‐neutral protocol can be applied to the synthesis of multisubstituted oxazolidine‐2,4‐diones with good chemoselectivity and good yields of isolated products under mild conditions. |
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| Keywords: | cyclization heterocycles oxothiolation synthetic methods ynamides |
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