Ring opening cross-metathesis on solid support: a combinatorial library synthesis of highly functionalized cyclopentanes |
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| Authors: | Cao Jingrong Cuny Gregory D Hauske James R |
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| Institution: | (1) Sepracor Inc., 111 Locke Dr., Marlborough, MA, 01752-7231, U.S.A |
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| Abstract: | Ruthenium catalyzed ring opening cross-metathesis of resin-bound bicyclic alkenes with terminal aryl olefins was utilized
for the construction of a combinatorial library containing highly functionalized cyclopentane derivatives. The technology
described herein represents a convergent method for the diastereospecific synthesis of unique cyclopentane molecular scaffolds
useful for exploratory medicinal chemistry.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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| Keywords: | cyclopentanes ring opening cross-methathesis ruthenium solid support |
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