| 氟尿嘧啶的电化学控制释放 |
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| 引用本文： | 黄华 刘柏峰. 氟尿嘧啶的电化学控制释放[J]. 分析化学, 1996, 24(2): 130-134 |
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| 作者姓名： | 黄华 刘柏峰 |
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| 作者单位： | 中国科学院长春应用化学研究所电分析化学开放研究实验室，国家电化学和光谱研究分析中心!长春130022(黄华，刘柏峰)，中国科学院长春应用化学研究所电分析化学开放研究实验室，国家电化学和 (董绍俊) |
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| 摘 要： | 本文探讨了抗癌药物氟尿嘧啶在聚吡咯膜修饰玻碳电极上的电化学控制释放，结果表明药物自膜中的释放是聚吡咯膜的电化学氧化还原过程决定的。其释放量可由还原电位进行控制，并与还原电量和膜厚呈现良好的线性关系。
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| 关 键 词： | 氟尿嘧啶 聚吡咯 化学修饰电极 控制释放 |
Electrochemically Controlled Release of 5-Fluorouracil |
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| Huang Hua, Liu Baifeng, Dong Shaojun. Electrochemically Controlled Release of 5-Fluorouracil[J]. Chinese Journal of Analytical Chemistry, 1996, 24(2): 130-134 |
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| Authors: | Huang Hua Liu Baifeng Dong Shaojun |
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| Abstract: | The electrochemically controlled release of 5-fluorouracil (5-FU ) from the polypyrrole (PPy) film on glassy carbon electrode is described. The result shows that the release of 5-FU from the PPy film depends on the electrochemical redox process of the PPy film. The release amount is controlled by reduction potential, and the amount of 5-FU released is proportional to the cathodic charge and thickness of the film. The exchange of 5-FU anions with chloride ions at open circuit is slow on the time scale of minutes, but release of the 5-FU anions can be compIeted in 100 s at -0. 6 V(vs. Ag/AgCl). The released amount of 5-FU is decreased with the time when the PPy film soaked in aqueous solution. |
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| Keywords: | Fluorouracil polypyrrole chemically modified electrode controlled release |
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