Triple asymmetric synthesis for fragment assembly: Validity of approximate multiplicativity of the three diastereofacial selectivities |
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| Authors: | Allen J. Duplantier Michael H. Nantz John C. Roberts Robert P. Short Peter Somfai Satoru Masamune |
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| Affiliation: | Department of Chemistry, Massachusetts Institute of Technology Cambridge, Massachusetts 02139 U.S.A. |
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| Abstract: | A strategy of triple asymmetric synthesis is illustrated to be effective for stereochemical control in fragment assembly, a task often encountered in convergent natural product synthesis. The stereochemical outcome of aldol reactions involving three chiral components supports a rule of approximate multiplicativity of facial selectivities intrinsic to the chiral reactants involved in each reaction. |
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