A novel and efficient methodology for the C-C bond forming radical cyclization of hydrophobic substrates in water |
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| Authors: | Kita Y Nambu H Ramesh N G Anilkumar G Matsugi M |
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| Institution: | Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamada-oka, Suita, Osaka 565-0871, Japan. kita@phs.osaka-u.ac.jp |
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| Abstract: | reaction: see text]. The combination of water-soluble radical initiator 2,2'-azobis2-(2-imidazolin-2-yl)propane] (VA-061), water-soluble chain carrier 1-ethylpiperidine hypophosphite (EPHP), and surfactant cetyltrimethylammonium bromide (CTAB) was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates. |
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